Fx7: Foundation Vitamin E

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Clinical Applications

  • Offers Antioxidant Protection for Cell Membranes and Lipids*
  • Supports Healthy Cytokine and Eicosanoid Balance*
  • Supports Cardiovascular, Nervous, and Reproductive Systems*
  • Provides Mixed Tocopherols and Tocotrienols

Fx7 Foundation-Vitamin E represents an advancement in vitamin E supplementation. This full-spectrum formula provides a blend of tocopherols—rather than just isolated alpha-tocopherol—and is the preferred form for long-term, daily supplementation of 200 IU or more. Clinical research suggests that vitamin E offers overall antioxidant support, especially for the cardiovascular system, nerves, eyes, and reproductive organs.*

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Vitamin E in its natural form comprises eight different compounds: alpha-, beta-, gamma-, and delta-tocopherols and alpha-, beta-, gamma-, and delta-tocotrienols. The most widely studied have been alpha-tocopherol and gamma-tocopherol—the two forms that exert the most antioxidant activity in the body and are found most abundantly in food. Alpha-tocopherol, in its natural d-alpha form, is the form primarily retained in the body and found circulating in the bloodstream. Gamma-tocopherol is the form found most abundantly in food, although heat and oxidation during cooking and processing can destroy it. Circulating levels of gamma-tocopherol are lower than those of alphatocopherol. Through its antioxidant activity, vitamin E is believed to support cardiovascular, neurological, and eye health. However, its initial discovery was based on its role in supporting healthy reproduction—hence the term tocopherol from the Greek “to bring forth offspring.” Ongoing research continues to shed light on various other roles that vitamin E and its constituents may play.[1-3]*

As an important fat-soluble antioxidant, alpha-tocopherol is capable of directly protecting cells and lipid-based molecules from the effects of free radicals and is incorporated into low-density lipoproteins (LDLs).[2,4] Supporting antioxidant activity within LDLs helps to maintain cholesterol integrity, normal white blood cell activity, and cytokine balance, which, in turn, supports cardiovascular health.[4,5] Another important aspect of vitamin E is that it protects fatty acids from oxidation, especially the polyunsaturated fatty acids found in cell membranes. Protection of cell membranes is crucial to the preservation of their function and integrity. Vitamin E requirements are believed to increase in erythrocytes, neurons, and lung epithelia as the polyunsaturated fatty acid content of their cell membranes increases.[6] Fx7 FoundationVitamin E provides a blend of tocotrienols and tocopherols, including 200 IU of alpha-tocopherol, to help meet the body’s requirement for vitamin E.*

Research in humans and animals suggests that supplementation with alpha-tocopherol addresses superoxide production, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and scavenger receptors SR-A and CD36, and further supports normal white blood cell health and foam cell levels. Supplementation also appears to promote healthy cytokine and eicosanoid balance through its effects on IL-8, plasminogen activator inhibitor-1, C-reactive protein (CRP), protein kinase C, 5-lipoxygenase, tyrosine-kinase, and cyclooxygenase-2, as well as its support of endothelium cell integrity.[5] Vitamin E is believed to play a role in balancing arachidonic acid and prostacyclin, thereby supporting normal blood vessel dilation and healthy platelet function.[4] Research utilizing a double-blinded parallel design suggests that serum gamma-tocopherol levels increased significantly relative to dose, and all subjects receiving gamma-tocopherol supplementation experienced significant support of LDL cholesterol, platelet aggregation, and mean platelet volume.*[1]

Research suggests that levels of gamma-tocopherol actually decreased with isolated alpha-tocopherol supplementation. In addition, the combination of gamma-tocopherol and alpha-tocopherol appears to positively support healthy levels of high sensitivity CRP and nitrotyrosine.[7,8] Gamma-tocopherol has also been recognized for its importance in maintaining prostate health. A study of 10,456 males suggests that “statistically significant protective associations for high levels of selenium and alpha-tocopherol were observed only when gamma-tocopherol concentrations were high.”[9] Ironically, research studies often incorporate only synthetic “all-rac-” (dl-alpha-tocopherol) into study designs, including prostate health studies.*

Further research indicates that tocotrienol components of vitamin E exert their own distinct effects in the body and support nervous system health and cell-life regulation, as well as cholesterol and AGE (advanced glycosylated end-product) levels already within the normal range. [10-12] As prior research on isolated alpha-tocopherol and synthetic dl-alpha-tocopherol is recognized as incomplete and inconclusive, studies investigating the benefits of supplementing with a balanced form of vitamin E are under way. In addition, because the liver closely regulates vitamin E status in the body, researchers believe that potentially adverse effects from supplementation are limited.*[13]

Fx7 Foundation-Vitamin E is designed as a complete and complementary vitamin E supplement.